ReproSil Chiral-MOF

Immobilized Cellulose-Based Chiral Phase with Tris-(4-chlorophenyl)carbamate for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-MOF is a silica-based HPLC stationary phase with immobilized tris-(4-chlorophenyl)carbamate cellulose, designed for enantioselective separations under normal-phase conditions. The cellulose derivative substituted with 4-chlorophenyl carbamate groups provides a highly ordered chiral environment that enables precise and efficient enantiodiscrimination through hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity.

The electron-withdrawing chlorine substituents on the aromatic rings enhance the π-acceptor character of the carbamate groups and influence the overall polarity of the selector, resulting in distinct selectivity and strong chiral recognition for a wide variety of racemic compounds. The covalent immobilization of the cellulose derivative on high-purity spherical silica ensures exceptional chemical and mechanical stability, allowing the use of both standard and unconventional solvent systems without loss of chiral performance. ReproSil Chiral-MOF provides consistent retention behavior, excellent column lifetime, and reproducible results, even under demanding analytical or preparative conditions. It is ideally suited for pharmaceutical, biochemical, and chemical laboratories that require robust, high-resolution chiral separations and flexible solvent compatibility for method development and routine enantioselective analyses.

ReproSil Chiral-MOF combines the chiral recognition efficiency of cellulose tris-(4-chlorophenyl)carbamate with the robustness of immobilized silica technology – the reliable choice for accurate, flexible, and reproducible enantioselective separations in normal-phase chromatography.

Key Features:

• Silica-based stationary phase with immobilized tris-(4-chlorophenyl)carbamate cellulose

• Designed for enantioselective separations under normal-phase conditions

• Strong chiral recognition through hydrogen bonding, π–π stacking, and dipole–dipole interactions

• Distinct selectivity due to the electronic effects of chlorine substituents

• Exceptional chemical and mechanical stability due to covalent immobilization

• Extended solvent compatibility for flexible method development

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of pharmaceuticals, fine chemicals, and intermediates

• Analysis of racemic compounds containing aromatic or halogenated substituents

• Method development and chiral screening under normal-phase conditions

• Quality control and stereochemical purity testing in pharmaceutical and chemical research