ReproSil Chiral
HPLC Columns for Enantiomer Separation and Chiral Selectivity
ReproSil Chiral is a column series from Dr. Maisch HPLC GmbH developed for the separation of enantiomers and other chiral isomers using high-performance liquid chromatography (HPLC). These columns are based on high-purity, fully porous silica, coated or covalently bonded with chiral selectors such as amylose, cellulose, or cyclodextrin derivatives. ReproSil Chiral columns provide high stereoselectivity, robust retention, and reproducible resolution for a broad range of chiral compounds.
They are suitable for use in both normal-phase and polar organic or reversed-phase modes, depending on the selector and application.
ReproSil Chiral columns from Dr. Maisch HPLC GmbH offer precise and reliable enantiomer separations – ideal for laboratories focused on chiral HPLC, enantioselective method development, and regulatory testing.
Specifications
| Particle Sizes | 3 – 20 µm |
|---|---|
| Phases/Modifications | α1-acid glycoprotein, β-Cyclodextrin, 3-(Phenylcarbamat)-Cellulose, Human serum albumin, L-Prolin, L-Hydroxy-Prolin, N-(3,5-Dinitrobenzoyl)-D-Phenylglycin, N-(3,5-Dinitrobenzoyl)-L-Leucin, N-(3,5-Dinitrobenzoyl)-L-Phenylglycin, Teicoplanin Aglycon, Teicoplanin, Tris-(3,5-dimethylphenyl)carbamat-Amylose, Tris-(S)-α-methylbenzylcarbamat-Amylose, Tris-Benzoat-Cellulose, Tris-(4-methylphenyl)carbamat-Cellulose, Tris-(4-methylbenzoyl)carbamate-Cellulose, Tris-(3,5-dimethylphenyl)carbamat-Cellulose, Tris-(3,5-dichlorophenyl)carbamat-Cellulose, Tris-(3-chlorophenyl)carbamat-Amylose, Tris-(3-chloro-4-methylphenyl)carbamat-Amylose, Tris-(4-chloro-3-methylphenyl)carbamat-Cellulose, Tris-(3-chloro-4-methylphenyl)carbamat-Cellulose, Tris-(4-chlorophenyl)carbamat-Cellulose, Tris-(5-chloro-2-methylphenyl)carbamat-Amylose |
| Pore Sizes | 100 Å, 300 Å, 1 000 Å |
| Surface Areas | 30 – 350 m²/g |
Key Features:
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Silica-based chiral phases with various selector types
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Excellent enantioselectivity and resolution
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Compatible with normal-phase, polar organic, and RP eluents
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Suitable for method development, QC, and regulatory environments
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Manufactured and quality-assured by Dr. Maisch HPLC GmbH
Typical Applications:
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Enantiomeric purity testing of chiral pharmaceuticals
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Separation of stereoisomers and racemic mixtures
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Chiral method development in drug discovery
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Chiral QC and compliance with regulatory guidelines