ReproSil Chiral-GM

Ajánlatkérés
Cikkszám: r65.gm. (5µm)
Gyártó: Dr. Maisch

Leírás és Paraméterek

Cellulose-Based Chiral Phase with Tris-(4-methylphenyl)carbamate Coating for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-GM is a silica-based HPLC stationary phase coated with tris-(4-methylphenyl)carbamate cellulose, specifically developed for enantioselective separations under normal-phase conditions. The cellulose tris-(4-methylphenyl)carbamate chiral selector enables multiple molecular interaction mechanisms – including hydrogen bonding, π–π stacking, and dipole–dipole interactions – providing strong chiral recognition and excellent resolution for a wide range of racemic compounds.

The carefully optimized coating process ensures a uniform and stable chiral layer on high-purity spherical silica, resulting in outstanding mechanical stability, reproducible retention behavior, and consistent enantioselectivity. The unique substitution pattern of the 4-methylphenylcarbamate groups imparts a distinct selectivity profile that complements other cellulose- and amylose-based chiral stationary phases, making ReproSil Chiral-GM particularly valuable for method development and screening in chiral HPLC.

This phase is ideally suited for pharmaceutical, chemical, and biochemical laboratories, offering reliable performance for both analytical and preparative enantioseparations in non-aqueous mobile phase systems such as n-hexane/alcohol mixtures.

ReproSil Chiral-GM combines cellulose-based chiral recognition with the selectivity of tris-(4-methylphenyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.

Particle Size
  • 5 µm
Pore Size 1 000 Å
Surface Area 30 m²/g
Phase/Modification Tris-(4-methylphenyl)carbamat-Cellulose
Particle Type
Separation Mode
Endcapping No
pH Range 2 to 8

Key Features:

  • Silica-based stationary phase coated with tris-(4-methylphenyl)carbamate cellulose

  • Designed for enantioselective separations under normal-phase conditions

  • Excellent chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions

  • Distinct selectivity profile complementary to other ReproSil Chiral phases

  • High mechanical stability and reproducibility under routine operation

  • Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

  • Enantioselective separation of chiral pharmaceuticals and intermediates

  • Analysis of racemic fine chemicals and natural products

  • Method development and screening in chiral normal-phase HPLC

  • Quality control and purity testing of optically active compounds