ReproSil Chiral-NR-R

Immobilized Brush-Type Chiral Phase with π–Electron Acceptor/Donor Functionality for Reversed Enantioselective Chromatography

ReproSil Chiral-NR-R is an immobilized brush-type chiral stationary phase featuring π–electron acceptor and donor functional groups, specifically developed for enantioselective separations with an inverse elution order compared to ReproSil Chiral-NR. This unique design enables complementary selectivity, providing alternative resolution behavior for compounds that exhibit opposite retention characteristics on the original NR phase.

The chiral selector combines aromatic donor–acceptor sites and stereochemically defined recognition centers, allowing chiral discrimination through π–π interactions, hydrogen bonding, dipole–dipole forces, and steric complementarity. This well-balanced interaction profile delivers precise and reproducible separations for a wide variety of racemic compounds, particularly aromatic, conjugated, and heteroaromatic molecules. The immobilized configuration ensures outstanding chemical and mechanical stability, allowing operation under a broad range of chromatographic conditions — including normal-phase, reversed-phase, and polar-organic modes — without loss of enantioselectivity or phase integrity. Supported by high-purity spherical silica, ReproSil Chiral-NR-R offers high efficiency, excellent column durability, and consistent performance in both analytical and preparative applications.

ReproSil Chiral-NR-R combines immobilized brush-type chiral recognition with π–electron donor/acceptor functionality and reversed elution characteristics – the reliable choice for precise, reproducible, and complementary enantioselective separations in advanced chiral chromatography.

Key Features:

• Immobilized brush-type chiral stationary phase with π–electron acceptor/donor functionality

• Inverse elution order compared to ReproSil Chiral-NR

• Strong chiral recognition through π–π interactions, hydrogen bonding, and dipole–dipole forces

• Exceptional chemical and mechanical stability under various solvent conditions

• Extended solvent compatibility for flexible method development

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of aromatic, conjugated, and heteroaromatic compounds

• Complementary selectivity and inverse elution behavior to ReproSil Chiral-NR

• Method development and optimization for complex racemic mixtures

• Quality control and stereochemical purity testing in pharmaceutical and chemical research