ReproSil Chiral-YM

Amylose-Based Chiral Phase with Tris-(5-chloro-2-methylphenyl)carbamate Coating for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-YM is a silica-based HPLC stationary phase coated with tris-(5-chloro-2-methylphenyl)carbamate amylose, specifically developed for enantioselective separations under normal-phase conditions. The amylose derivative functionalized with 5-chloro-2-methylphenyl carbamate groups offers a unique chiral recognition profile based on a combination of hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity.

The chlorine and methyl substituents on the aromatic rings influence the electronic and steric environment of the carbamate groups, providing a distinct selectivity pattern and complementary enantiorecognition behavior compared to other amylose-based phases. This makes ReproSil Chiral-YM particularly effective for the resolution of challenging racemic mixtures and an excellent choice for method development and chiral screening. The coating is applied to high-purity spherical silica, ensuring outstanding mechanical stability, reproducibility, and long column lifetime. Designed for use with typical non-aqueous mobile phases such as n-hexane/alcohol mixtures, this phase delivers excellent resolution, sharp peaks, and stable retention behavior across repeated analyses.

ReproSil Chiral-YM combines amylose-based chiral recognition with the unique selectivity of tris-(5-chloro-2-methylphenyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.

Attractive alternative to CHIRALPAK® AY-H (Daicel®) and Lux Amylose-2 (Phenomenex™).

Key Features:

• Silica-based stationary phase coated with tris-(5-chloro-2-methylphenyl)carbamate amylose

• Designed for enantioselective separations under normal-phase conditions

• Multiple interaction mechanisms for broad and selective chiral recognition

• Unique selectivity due to chlorine and methyl substituents on the aromatic rings

• High mechanical and chemical stability with reproducible performance

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of pharmaceuticals, fine chemicals, and intermediates

• Method development and screening in chiral normal-phase HPLC

• Analysis of racemic natural products and synthetic compounds

• Quality control and stereochemical purity testing in pharmaceutical and chemical industries