ReproSil Chiral-MIZ

Immobilized Cellulose-Based Chiral Phase with Tris-(3-chloro-4-methylphenyl)carbamate for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-MIZ is a silica-based HPLC stationary phase with immobilized tris-(3-chloro-4-methylphenyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The cellulose derivative, substituted with 3-chloro-4-methylphenyl carbamate groups, provides a well-balanced combination of electronic and steric effects, resulting in high chiral recognition capability and excellent resolution across a broad range of racemic compounds.

Chiral discrimination on ReproSil Chiral-MIZ occurs through multiple intermolecular interactions — including hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity — between analyte molecules and the immobilized chiral selector. The chlorine and methyl substituents on the aromatic rings fine-tune the polarity and π-acceptor properties of the selector, giving the phase a distinct and versatile selectivity profile for compounds with varying functional groups.

The chiral selector is covalently immobilized onto high-purity spherical silica, ensuring exceptional chemical and mechanical stability. This immobilization allows the use of a wide range of mobile phases, including polar and non-standard solvent systems, without loss of enantioselectivity or phase integrity. As a result, ReproSil Chiral-MIZ offers outstanding flexibility for both method development and routine enantioseparations. With its robust design and reproducible performance, ReproSil Chiral-MIZ is ideally suited for pharmaceutical, biochemical, and chemical applications, providing precise, high-resolution separations of chiral compounds under demanding analytical or preparative conditions.

ReproSil Chiral-MIZ combines the proven chiral recognition of cellulose tris-(3-chloro-4-methylphenyl)carbamate with the durability of immobilized silica technology – the reliable choice for accurate, robust, and reproducible enantioselective separations in normal-phase chromatography.

Key Features:

• Silica-based stationary phase with immobilized tris-(3-chloro-4-methylphenyl)carbamate cellulose

• Designed for enantioselective separations under normal-phase conditions

• Strong chiral recognition via hydrogen bonding, π–π stacking, and dipole–dipole interactions

• Unique selectivity influenced by chlorine and methyl substituents on the aromatic rings

• Covalent immobilization for enhanced chemical and solvent stability

• High mechanical strength and reproducible performance

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of pharmaceuticals, intermediates, and fine chemicals

• Analysis of racemic mixtures containing aromatic or halogenated substituents

• Method development and chiral screening in normal-phase and polar-organic modes

• Stereochemical purity testing and quality control in pharmaceutical and chemical research