ReproSil Chiral-ZA

Amylose-Based Chiral Phase with Tris-(3-chloro-4-methylphenyl) carbamate Coating for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-ZA is a silica-based HPLC stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate amylose, specifically developed for enantioselective separations under normal-phase conditions. The amylose derivative substituted with 3-chloro-4-methylphenyl carbamate groups provides a finely tuned balance of electronic and steric effects, resulting in strong and versatile chiral recognition across a wide range of racemic compounds.

Chiral discrimination on ReproSil Chiral-ZA arises from multiple molecular interactions — including hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity — allowing excellent resolution and sharp peak shapes. The unique substitution pattern of chlorine and methyl groups modulates the polarity and interaction strength of the carbamate groups, creating a distinct and complementary selectivity compared to other amylose-based chiral stationary phases. The phase is built on high-purity spherical silica, ensuring excellent mechanical strength, reproducibility, and long column lifetime. Its stable coating withstands routine analytical use and is fully compatible with standard non-aqueous mobile phases such as n-hexane/alcohol mixtures. ReproSil Chiral-ZA is ideally suited for both analytical and preparative chiral HPLC in pharmaceutical, chemical, and biochemical laboratories.

ReproSil Chiral-ZA combines amylose-based chiral recognition with the tailored selectivity of tris-(3-chloro-4-methylphenyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.

Attractive alternative to CHIRALPAK® AZ-H (Daicel®).

Key Features:

• Silica-based stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate amylose

• Designed for enantioselective separations under normal-phase conditions

• Strong chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions

• Unique electronic and steric selectivity due to chlorine and methyl substituents

• High mechanical stability and reproducible retention behavior

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of chiral pharmaceuticals and intermediates

• Method development and screening in chiral normal-phase HPLC

• Analysis of racemic natural products, agrochemicals, and fine chemicals

• Stereochemical purity control in pharmaceutical and chemical research