ReproSil Chiral-D-PhenylGlycin

Silica-Based Brush-Type Chiral Phase with N-(3,5-Dinitrobenzoyl)-D-Phenylglycine for Enantioselective Chromatography

ReproSil Chiral-D-PhenylGlycin is a silica-based HPLC stationary phase of the brush-type Pirkle design, modified with N-(3,5-dinitrobenzoyl)-D-phenylglycine as the chiral selector. This phase is specifically developed for the enantioselective separation of herbicides, pharmaceuticals, and other aromatic chiral compounds. Its well-defined molecular architecture allows precise chiral recognition through donor–acceptor complexation, hydrogen bonding, π–π interactions, and steric complementarity.

The D-phenylglycine moiety serves as the chiral recognition center, while the electron-withdrawing 3,5-dinitrobenzoyl group provides strong π–acceptor properties, enabling high-resolution separations of analytes containing electron-donating aromatic or heteroaromatic groups. This makes ReproSil Chiral-D-PhenylGlycin particularly effective for compounds such as phenoxyacetic acid herbicides, pharmaceutical intermediates, and other aromatic chiral molecules. The chiral selector is covalently bound to high-purity spherical silica, ensuring excellent mechanical stability, solvent resistance, and reproducible performance. The phase can be used under normal-phase, reversed-phase, or polar-organic conditions, offering flexibility for a wide range of enantioselective separations in analytical and preparative applications.

ReproSil Chiral-D-PhenylGlycin combines the strong π–acceptor capability of the N-(3,5-dinitrobenzoyl) group with the chiral recognition power of D-phenylglycine – the reliable choice for precise and reproducible enantioselective separations of herbicides, pharmaceuticals, and aromatic chiral compounds.

Attractive Alternative to Nucleosil Chiral-2 (Macherey-Nagel).

Key Features:

• Silica-based brush-type chiral stationary phase with N-(3,5-dinitrobenzoyl)-D-phenylglycine

• Developed for enantioselective separations of herbicides, pharmaceuticals, and aromatic chiral compounds

• Strong enantioselectivity via donor–acceptor, hydrogen bonding, and π–π interactions

• Covalently bonded chiral selector for high stability and reproducibility

• Applicable in normal-phase, reversed-phase, and polar-organic chromatography

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of phenoxyacetic acid herbicides and related agrochemicals

• Resolution of aromatic and heteroaromatic chiral pharmaceuticals and intermediates

• Method development for compounds with π–electron-donating functional groups

• Quality control and stereochemical purity testing in pharmaceutical and chemical research