ReproSil Chiral-MIB

Immobilized Cellulose-Based Chiral Phase with Tris-(3,5-dimethylphenyl)carbamate for Enantioselective Normal-Phase Chromatography

ReproSil Chiral-MIB is a silica-based HPLC stationary phase with immobilized tris-(3,5-dimethylphenyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The immobilized cellulose derivative provides strong and broad chiral recognition through hydrogen bonding, π–π interactions, dipole–dipole forces, and steric complementarity, enabling high-resolution separations for a wide range of racemic compounds.

Unlike conventional coated cellulose-based chiral phases, ReproSil Chiral-MIB features a covalently immobilized chiral selector, ensuring exceptional chemical and mechanical stability. This immobilization allows the use of a wider range of mobile phases, including polar or non-standard solvents, without compromising the phase’s chiral recognition performance. As a result, it provides greater flexibility and reliability for method development and robust enantioseparation workflows. Built on high-purity spherical silica, the phase exhibits excellent column efficiency, reproducible retention, and long operational lifetime. ReproSil Chiral-MIB is ideally suited for pharmaceutical, chemical, and biochemical applications, offering consistent and accurate enantioseparations in both analytical and preparative scales.

ReproSil Chiral-MIB combines the proven chiral recognition power of cellulose tris-(3,5-dimethylphenyl)carbamate with the durability of immobilized silica technology – the reliable choice for precise, flexible, and reproducible enantioselective separations in normal-phase chromatography.

Attractive alternative to CHIRALPAK® IB (Daicel®) and YMC Cellulose-SB (YMC).

Key Features:

• Silica-based stationary phase with immobilized tris-(3,5-dimethylphenyl)carbamate cellulose

• Designed for enantioselective separations under normal-phase conditions

• Strong chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions

• Immobilized coating for enhanced chemical robustness and solvent compatibility

• High-purity spherical silica for mechanical stability and reproducibility

• Suitable for analytical and preparative chiral HPLC applications

Typical Applications:

• Enantioselective separation of pharmaceuticals, intermediates, and fine chemicals

• Method development requiring polar or mixed mobile phases

• Routine chiral screening and optimization in pharmaceutical and chemical analysis

• Quality control and stereochemical purity determination in research and production